This study investigates industrial land-use planning in Sistan and Baluchistan province, focusing on enhancing defense capabilities. Land-use planning is vital for spatial organization and optimal resource utilization, contributing significantly to sustainable development. The research aims to evaluate the distribution and dispersion of industries in the province, considering defense-related criteria, regional advantages, and environmental factors. It addresses the strategic importance of industrial placement to balance economic growth, environmental sustainability, and defense considerations. The study employs a descriptive-analytical approach, collecting data from library resources, including the Ministry of Industry, Mine and Trade, the Statistical Center of Iran, and research working groups. The TOPSIS multi-criteria decision-making method was used to rank industries based on ten defense-related criteria, such as water consumption, export competitiveness, and environmental risks. Data analysis was conducted using SPSS and Excel, with spatial distribution maps illustrating industrial patterns. Findings reveal that small and medium-sized industries are concentrated in cities like Zahedan, Zabol, Saravan, and Chabahar, while three counties lack active industrial units. Food, non-metallic mineral, and chemical industries dominate, comprising over 70% of units. The criterion of low water consumption significantly impacts industrial security. The uneven industrial distribution indicates a misalignment with land-use planning principles, potentially leading to social insecurities. The study underscores the need for balanced industrial planning to enhance regional security and sustainable development.